SCHEMBL3138264

SCHEMBL3138264

NC1=NCC(COc2ccc(Cl)c(Cl)c2)O1

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.38
ALDH1A1 P00352 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
GRM2 Q14416 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3142923 0.86 NSD2 (0.42)
SCHEMBL3135510 0.84 GRM2 (0.50) GRM2
SCHEMBL7842308 0.82 TAAR1 (0.57) ALDH1A1TAAR1GRM2
SCHEMBL3144469 0.82 RAB9A (0.42) ALDH1A1GRM2
SCHEMBL3148324 0.81 DRD4 (0.39) ALDH1A1
SCHEMBL3135569 0.78 PARP15 (0.40) KDM4EGRM2
SCHEMBL3148352 0.78 ALOX15 (0.43) ALDH1A1
SCHEMBL3138790 0.78 SMN1; SMN2 (0.41) KDM4EALDH1A1
SCHEMBL1513582 0.78 TSHR (0.41) ALDH1A1GRM2
SCHEMBL27778759 0.78 ALOX5 (0.39) GRM2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12503695-B2 RAB13 and NET1 antisense oligonucleotides to treat metastatic cancer THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2025-12-23 US disclosed
CN-120006265-A Copper-based chemical nickel plating method 厦门大学 2025-05-16 CN disclosed
WO-2025072713-A1 POLYMYXINS FOR DELIVERY OF AGENTS TO THE KIDNEY JUDO BIO, INC. (US) 2025-04-03 WO disclosed
US-20250111889-A1 DE NOVO DESIGNED MACROCYCLIC OLIGOAMIDES UNIVERSITY OF WASHINGTON 2025-04-03 US disclosed
WO-2025072699-A1 AMINOGLYCOSIDES FOR DELIVERY OF AGENTS TO THE KIDNEY JUDO BIO, INC. (US) 2025-04-03 WO disclosed
EP-4499712-A2 TARGETED DELIVERY Judo Bio Inc. (US) 2025-02-05 EP disclosed
EP-4472997-A2 TARGETING MOIETIES PROMOTING TRANSDUCTION OF CENTRAL NERVOUS SYSTEM CELLS AND TISSUES AND METHODS OF USE The Broad Institute, Inc. (US) 2024-12-11 EP disclosed
CN-119101089-A Oligonucleotide synthesis process of chimeric PMO structure 苏州盛诺维生物科技有限公司 2024-12-10 CN disclosed
CN-118988400-A Efficient and stable catalyst and preparation method and application thereof 浙江大学 2024-11-22 CN disclosed
CN-118616096-B Alumina-supported composite catalyst and preparation method and application thereof 浙江大学 2024-11-22 CN disclosed
WO-2023183628-A2 TARGETED DELIVERY JUDO BIO INC. (US) 2023-09-28 WO disclosed
WO-2023150632-A2 TARGETING MOIETIES PROMOTING TRANSDUCTION OF CENTRAL NERVOUS SYSTEM CELLS AND TISSUES AND METHODS OF USE THE BROAD INSTITUTE, INC. (US) 2023-08-10 WO disclosed
CN-110909787-B Method and system for optimizing multi-target batch scheduling based on cluster evolution algorithm 安徽大学 2023-05-12 CN disclosed
US-20230057461-A1 RAB13 AND NET1 ANTISENSE OLIGONUCLEOTIDES TO TREAT METASTATIC CANCER THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-02-23 US disclosed
JP-2022071540-A RADIO COMMUNICATION SYSTEM, ADMINISTRATIVE SERVER AND COMMUNICATION METHOD 日本電信電話株式会社 2022-05-16 JP disclosed
EP-2137193-B1 SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF SANOFI SA (FR) 2017-08-09 EP disclosed
US-8642603-B2 Substituted dihydro and tetrahydro oxazolopyrimidinones, preparation and use thereof SANOFI (FR) 2014-02-04 US disclosed
US-20100075994-A1 SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF SANOFI-AVENTIS (FR) 2010-03-25 US disclosed
US-4499090-A N-(5-aminomethyl-2-oxazolin-2-yl)-N'-phenylureas, compositions and use SOCIETE CORTIAL, S.A. (FR) 1985-02-12 US disclosed
US-4497812-A ANTIHISTIMINES;ANTINFLAMMATORY AGENTS;ANTIALLERGENS;DIURETICS;CARDIOVASCULAR THERAPY SOCIETE CORTIAL, S.A. (FR) 1985-02-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100075994-A1 SUBSTITUTED DIHYDRO AND TETRAHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF GRM2, GRM1, GRIN2C KDM4E 1354/4885ALDH1A1 1875/4885TAAR1 284/4885
US-20250111889-A1 DE NOVO DESIGNED MACROCYCLIC OLIGOAMIDES DHFR, CCNH, ODC1 KDM4E 2667/4885ALDH1A1 4524/4885TAAR1 4318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.