Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5109028 | 0.91 | F10 (0.45) | F10CYP2C9 | |
| SCHEMBL1406097 | 0.88 | F10 (0.55) | F10ALDH1A1TSHR | |
| SCHEMBL1405846 | 0.88 | F10 (0.55) | F10ALDH1A1TSHR | |
| SCHEMBL14078392 | 0.86 | F10 (0.47) | F10GAACYP2C9 | |
| SCHEMBL1405985 | 0.78 | F10 (0.54) | F10 | |
| SCHEMBL1406028 | 0.78 | F10 (0.54) | F10 | |
| SCHEMBL14078385 | 0.78 | FPR2 (0.53) | ALDH1A1KMT2ACYP2C9 | |
| SCHEMBL5440571 | 0.78 | F10 (0.60) | F10 | |
| SCHEMBL5440576 | 0.78 | F10 (0.60) | F10 | |
| SCHEMBL1405889 | 0.74 | F10 (0.52) | F10ALDH1A1TSHRKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597244-B1 | ETHYNYL DERIVATIVES SERVING AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2010-07-07 | — | — | EP | disclosed |
| US-7427618-B2 | Ethynyl derivatives as factor Xa inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-09-23 | — | — | US | disclosed |
| US-7427618-B2 | Ethynyl derivatives as factor Xa inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-09-23 | — | — | US | disclosed |
| US-7427618-B2 | Ethynyl derivatives as factor Xa inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-09-23 | — | — | US | disclosed |
| US-20060084648-A1 | Ethynyl derivatives as factor xa inhibitors | MERCK PATENT GMBH (DE) | 2006-04-20 | — | — | US | disclosed |
| EP-1597244-A1 | ETHYNYL DERIVATIVES SERVING AS FACTOR XA INHIBITORS | MERCK PATENT GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004076429-A1 | ETHYNYL DERIVATIVES SERVING AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2004-09-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084648-A1 | Ethynyl derivatives as factor xa inhibitors | F12, F11, SERPINC1 | F10 4/4885ALDH1A1 1869/4885TSHR 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.