SCHEMBL31389433

SCHEMBL31389433

OC1CC(n2ccnc2C(F)(F)F)C1

nearest known ligand 0.32

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SPR P35270 1/20 0.32
AR P10275 1/20 0.31
LRRK2 Q5S007 1/20 0.31
LMNA P02545 1/20 0.30
ABL1 P00519 1/20 0.30
EGFR P00533 1/20 0.30
ABL2 P42684 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methane SCHEMBL27920978 0.76 LMNA (0.40) SPRLMNA
SCHEMBL31389571 0.70 HPSE (0.36) LMNAABL1EGFRABL2
SCHEMBL18702013 0.69 SPR (0.45) SPRLRRK2LMNA
SCHEMBL31389636 0.67 POLB (0.36) LRRK2
SCHEMBL31389760 0.66 IDO1 (0.33) AR
SCHEMBL31389485 0.64 POLB (0.58)
SCHEMBL31389987 0.62 LRRK2 (0.43) SPRARLRRK2
SCHEMBL31390069 0.62 HTR2A (0.34) AR
SCHEMBL31389544 0.62 CDK5 (0.36) SPRAR
SCHEMBL20518476 0.61 MEN1 (0.32) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025043225-A2 DEGRADERS OF CYCLIN-DEPENDENT KINASE 2 GENENTECH, INC. (US) 2025-02-27 WO disclosed