Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31389636 | 0.79 | POLB (0.36) | POLBMAPTTP53 | |
| SCHEMBL31389529 | 0.79 | CCR5 (0.47) | MAPTTP53ALDH1A1TSHRMAPK1 | |
| SCHEMBL31389457 | 0.78 | POLB (0.53) | POLBMAPTTP53PDE4BPDE4D | |
| SCHEMBL31389550 | 0.78 | POLB (0.37) | POLBMAPTTP53 | |
| SCHEMBL15205240 | 0.76 | PDE10A (0.70) | POLBMAPTPDE10A | |
| SCHEMBL15205239 | 0.76 | PDE10A (0.70) | POLBMAPTPDE10A | |
| SCHEMBL15205015 | 0.76 | POLB (0.48) | POLBMAPTTP53PDE4BPDE4D | |
| SCHEMBL15205013 | 0.76 | POLB (0.48) | POLBMAPTTP53PDE4BPDE4D | |
| SCHEMBL31389453 | 0.76 | KDM4E (0.39) | POLBMAPTPDE4BPDE4DALDH1A1 | |
| SCHEMBL31660999 | 0.75 | POLB (0.46) | POLBMAPTTP53PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025043225-A2 | DEGRADERS OF CYCLIN-DEPENDENT KINASE 2 | GENENTECH, INC. (US) | 2025-02-27 | — | — | WO | disclosed |