SCHEMBL31389655

SCHEMBL31389655

OC1CC(F)(c2cccnc2OC(F)(F)F)C1

nearest known ligand 0.40

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.40
P2RX7 Q99572 3/20 0.36
ROCK2 O75116 2/20 0.34
SSTR4 P31391 9/20 0.33
NR1I2 O75469 1/20 0.33
SSTR1 P30872 7/20 0.33
PRCP P42785 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31389511 0.85 PDK2 (0.43) PDK2P2RX7ROCK2SSTR4SSTR1
SCHEMBL31389914 0.77 P2RX7 (0.37) P2RX7ROCK2PRCP
SCHEMBL31389421 0.71 HTR1A (0.42) SSTR4SSTR1
SCHEMBL31389735 0.71 MAPT (0.38) P2RX7ROCK2
SCHEMBL31389819 0.68 CNR2 (0.37) PDK2P2RX7ROCK2PRCP
SCHEMBL20270260 0.68 SLC6A4 (0.38) P2RX7
SCHEMBL18320509 0.67 TLR7 (0.47)
SCHEMBL30785493 0.67 TLR7 (0.47)
SCHEMBL15473322 0.64 CBFB (0.42) SSTR4
SCHEMBL31389417 0.64 P2RX7 (0.38) P2RX7SSTR4SSTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025043225-A2 DEGRADERS OF CYCLIN-DEPENDENT KINASE 2 GENENTECH, INC. (US) 2025-02-27 WO disclosed