SCHEMBL31389672

SCHEMBL31389672

CC(C)(C)[Si](C)(C)OC1CC(c2cccnc2OC(F)(F)F)C1

nearest known ligand 0.38

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HTR1A P08908 9/20 0.38
SLC6A2 P23975 9/20 0.38
SLC6A4 P31645 9/20 0.38
SLC6A3 Q01959 3/20 0.38
PDE10A Q9Y233 5/20 0.36
SSTR1 P30872 2/20 0.34
SSTR4 P31391 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31389723 0.82 PROKR1 (0.36)
SCHEMBL31389612 0.81 SSTR4 (0.34) SSTR1SSTR4
SCHEMBL31389531 0.78 TSHR (0.39)
SCHEMBL31389421 0.78 HTR1A (0.42) HTR1ASLC6A2SLC6A4SLC6A3PDE10A
SCHEMBL31389573 0.75 HTR2C (0.32) HTR1ASLC6A2SLC6A4
SCHEMBL31389576 0.70 SLC16A3 (0.31)
SCHEMBL31389604 0.68
SCHEMBL31389523 0.68 HTR1A (0.36) HTR1A
SCHEMBL16334250 0.67 PDE10A (0.33) PDE10A
SCHEMBL31389893 0.67 NR3C1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025043225-A2 DEGRADERS OF CYCLIN-DEPENDENT KINASE 2 GENENTECH, INC. (US) 2025-02-27 WO disclosed