Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083681 | 1.00 | NLRP3 (0.40) | NLRP3MAPTL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5591669 | 0.84 | NLRP3 (0.41) | NLRP3KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL30697576 | 0.82 | KMT2A (0.38) | NLRP3MAPTKDM4EALDH1A1TSHR | |
| SCHEMBL10362298 | 0.82 | KMT2A (0.38) | NLRP3MAPTKDM4EALDH1A1TSHR | |
| SCHEMBL17869461 | 0.79 | MEN1 (0.42) | NLRP3KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL10513126 | 0.79 | FDPS (0.36) | ALDH1A1TSHRMEN1KMT2ACYP1A2 | |
| SCHEMBL21672154 | 0.79 | ALDH1A1 (0.46) | MAPTL3MBTL1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL27710074 | 0.77 | MEN1 (0.35) | ALDH1A1TSHRMEN1KMT2AFDPS | |
| SCHEMBL29427328 | 0.77 | MEN1 (0.32) | MEN1KMT2A | |
| SCHEMBL24900643 | 0.76 | ALDH1A1 (0.36) | NLRP3KDM4EALDH1A1HPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054427-B1 | AVERMECTIN DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2010-07-14 | — | — | EP | disclosed |
| CN-101528761-A | Avermectin derivatives | BAYER CROPSCIENCE AG (DE) | 2009-09-09 | — | — | CN | disclosed |
| EP-2054427-A2 | AVERMECTIN DERIVATIVES | Bayer CropScience AG (DE) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019784-A2 | AVERMECTIN DERIVATIVES | BAYER CROPSCIENCE AG (DE) | 2008-02-21 | — | — | WO | disclosed |