Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31395345 | 0.79 | HSPB1 (0.58) | MEN1KMT2ALMNAL3MBTL1HTT | |
| SCHEMBL31395363 | 0.77 | TRPA1 (0.49) | TRPA1MEN1KMT2AKDM4ECYP2C9 | |
| SCHEMBL31395551 | 0.77 | KMT2A (0.47) | PTGER4MEN1KMT2ASMN1; SMN2HTT | |
| SCHEMBL31395515 | 0.75 | PDE10A (0.53) | TRPA1KMT2ACYP2C9LMNASMN1; SMN2 | |
| SCHEMBL31395533 | 0.75 | CYP1A2 (0.40) | PTGER4CYP2C9SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL4448799 | 0.73 | PTGER4 (0.62) | PTGER4MEN1KMT2A | |
| SCHEMBL933336 | 0.73 | S100A9 (0.36) | CYP2C9CYP3A4 | |
| SCHEMBL22866766 | 0.70 | RXRA (0.34) | — | |
| SCHEMBL20304947 | 0.70 | HPGD (0.38) | KDM4ELMNATSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL29561048 | 0.70 | RXRA (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739307-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | The General Hospital Corporation (US) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025010291-A2 | TARGETED EPIGENETIC THERAPIES FOR DISORDERS OF PROGRANULIN DEFICIENCY | THE GENERAL HOSPITAL CORPORATION (US) | 2025-01-09 | — | — | WO | disclosed |