SCHEMBL31401142

SCHEMBL31401142

Cc1ccc(Br)cc1C1COCCO1

nearest known ligand 0.35

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.35
HTT P42858 2/20 0.35
LMNA P02545 1/20 0.35
BLM P54132 1/20 0.35
HPGD P15428 1/20 0.33
ALDH1A1 P00352 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
POLB P06746 1/20 0.31
HTR2A P28223 1/20 0.30
HTR2C P28335 1/20 0.30
HTR2B P41595 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31401405 0.86 MAPT (0.40) MAPTHTTHPGDALDH1A1POLB
SCHEMBL31401324 0.86 MAPT (0.40) MAPTHTTHPGDALDH1A1POLB
SCHEMBL2276882 0.78 HTT (0.36) MAPTHTTLMNABLMHPGD
SCHEMBL21603112 0.77 LMNA (0.33) MAPTHTTLMNABLM
SCHEMBL8889457 0.76 TAAR1 (0.44) ALDH1A1HTR2AHTR2CHTR2B
SCHEMBL31401440 0.76 TSHR (0.39) HTTALDH1A1L3MBTL1
SCHEMBL20522658 0.75 USP2 (0.35) MAPTLMNAALDH1A1L3MBTL1
SCHEMBL28917603 0.75 ALDH1A1 (0.40) MAPTHTTHPGDALDH1A1L3MBTL1
SCHEMBL8250970 0.72 TSHR (0.40) HTR2CHTR2B
SCHEMBL30623726 0.72 MAPT (0.40) MAPTHTTHPGDALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4739682-A1 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS Janssen Pharmaceutica NV (BE) 2026-05-13 EP disclosed
WO-2025008058-A1 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS JANSSEN PHARMACEUTICA NV (BE) 2025-01-09 WO disclosed