Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | CDC25B | P30305 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31401033 | 0.83 | ALDH1A1 (0.43) | SMN1; SMN2KMT2APOLBESR1RECQL | |
| SCHEMBL16398545 | 0.80 | HCAR3 (0.36) | PKMTDP1HCAR3MAPTALDH1A1 | |
| SCHEMBL19859253 | 0.77 | ELANE (0.43) | PKMNPSR1TDP1HCAR3MAPT | |
| SCHEMBL19003378 | 0.74 | HCAR3 (0.41) | PKMPOLBTDP1L3MBTL1HCAR3 | |
| SCHEMBL3256088 | 0.72 | MAPT (0.44) | SMN1; SMN2KMT2APOLBTDP1L3MBTL1 | |
| SCHEMBL14799008 | 0.72 | PKM (0.50) | PKMKMT2ANPSR1POLBMAPT | |
| SCHEMBL9436774 | 0.71 | HCAR3 (0.57) | PKMCDC25BSMN1; SMN2KMT2APOLB | |
| SCHEMBL5405584 | 0.71 | CDC25B (0.53) | PKMCDC25BSMN1; SMN2KMT2ANPSR1 | |
| SCHEMBL6232759 | 0.71 | RXRA (0.42) | KMT2APOLBTDP1ALDH1A1CA12 | |
| SCHEMBL19985139 | 0.70 | HCAR3 (0.38) | PKMTDP1HCAR3MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4739682-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | Janssen Pharmaceutica NV (BE) | 2026-05-13 | — | — | EP | disclosed |
| WO-2025008058-A1 | 1,6-NAPHTHRIDINE COMPOUNDS AS SMARCA2 INHIBITORS USEFUL FOR THE TREATMENT OF SMARCA4 DEFICIENT CANCERS | JANSSEN PHARMACEUTICA NV (BE) | 2025-01-09 | — | — | WO | disclosed |