Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3136953 | 0.82 | POLB (0.40) | HDAC6ADORA2AADORA1KDM4EMAPT | |
| SCHEMBL3128146 | 0.81 | GRIN2D (0.35) | KDM4EMAPTEGLN1HTT | |
| SCHEMBL3133401 | 0.78 | NQO1 (0.37) | HDAC6MAPT | |
| SCHEMBL15567755 | 0.77 | GABRP (0.39) | KDM4EMAPTL3MBTL1HTT | |
| SCHEMBL2105708 | 0.76 | SMAD3 (0.49) | KDM4EGLAMAPT | |
| SCHEMBL30147596 | 0.76 | SMAD3 (0.49) | KDM4EGLAMAPT | |
| SCHEMBL3136216 | 0.75 | — | — | |
| SCHEMBL3381954 | 0.74 | FLT3 (0.48) | HDAC6 | |
| SCHEMBL4036808 | 0.73 | DAO (0.51) | MAPTHTT | |
| SCHEMBL3381701 | 0.71 | HRH4 (0.43) | MMP2MMP9MMP8MMP13KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636224-B1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE | PROSIDION LTD (GB) | 2010-07-14 | — | — | EP | claimed |