Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12614229 | 0.82 | SIRT2 (0.46) | SIRT2SIRT1MTNR1AMTNR1BENPP3 | |
| SCHEMBL3140892 | 0.82 | HDAC6 (0.33) | KDM4EL3MBTL1ADORA2AADORA1MAPT | |
| SCHEMBL15567755 | 0.80 | GABRP (0.39) | ALDH1A1KDM4EL3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL3128146 | 0.79 | GRIN2D (0.35) | POLBSIRT2ALDH1A1KDM4EMAPT | |
| SCHEMBL2107849 | 0.79 | PIN1 (0.47) | POLBTDP1SIRT2SIRT1MTNR1A | |
| SCHEMBL30310720 | 0.79 | PIN1 (0.47) | POLBTDP1SIRT2SIRT1MTNR1A | |
| SCHEMBL3133401 | 0.75 | NQO1 (0.37) | ENPP1MAPTKMT2AHDAC6 | |
| SCHEMBL30310722 | 0.75 | NNMT (0.46) | POLBTDP1SIRT2SIRT1MTNR1A | |
| SCHEMBL3754482 | 0.75 | XDH (0.47) | SIRT2SIRT1MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL4034495 | 0.75 | NNMT (0.46) | POLBTDP1SIRT2SIRT1MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636224-B1 | PYRROLOPYRIDINE-2-CARBOXYLIC ACID AMIDE INHIBITORS OF GLYCOGEN PHOSHORYLASE | PROSIDION LTD (GB) | 2010-07-14 | — | — | EP | claimed |