Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 12/20 | 0.35 |
| ▸ | THRB | P10828 | 12/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3142062 | 0.87 | THRA (0.38) | THRATHRBPPARG | |
| SCHEMBL3142258 | 0.75 | THRA (0.36) | THRATHRBPPARG | |
| SCHEMBL3128023 | 0.74 | ACSS2 (0.35) | THRATHRBPPARG | |
| SCHEMBL3136098 | 0.74 | ACSS2 (0.35) | THRATHRBPPARG | |
| SCHEMBL3127197 | 0.73 | THRA (0.35) | THRATHRBPPARG | |
| SCHEMBL3130577 | 0.73 | ACSS2 (0.40) | THRATHRBPPARG | |
| SCHEMBL3133600 | 0.73 | ACSS2 (0.40) | THRATHRBPPARG | |
| SCHEMBL3142133 | 0.73 | POLB (0.45) | THRATHRB | |
| SCHEMBL3137672 | 0.72 | RAF1 (0.37) | THRATHRB | |
| SCHEMBL3137299 | 0.71 | THRA (0.39) | THRATHRBPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | TSHR, GHSR, TRHR | THRA 4/4885THRB 6/4885NR1H4 150/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.