SCHEMBL31411707

SCHEMBL31411707

CC1(C)C(=O)Nc2cc(Br)sc21

nearest known ligand 0.37

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 1/20 0.37
PDK4 Q16654 1/20 0.37
ATAD2 Q6PL18 1/20 0.36
PGR P06401 7/20 0.36
ABCC8 Q09428 1/20 0.34
KCNJ11 Q14654 1/20 0.34
BACE1 P56817 3/20 0.33
HTR6 P50406 2/20 0.32
BACE2 Q9Y5Z0 2/20 0.31
IDO1 P14902 1/20 0.31
PDE3B Q13370 4/20 0.31
PDE3A Q14432 4/20 0.31
PDE4A P27815 3/20 0.31
PDE4B Q07343 3/20 0.31
PDE4C Q08493 3/20 0.31
PDE4D Q08499 3/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31411583 0.73 PGR (0.51) PDK2PDK4ATAD2PGR
SCHEMBL31411589 0.69 ALDH1A1 (0.40)
SCHEMBL12965826 0.67 PDK2 (0.50) PDK2PDK4ATAD2PGRPDE3B
SCHEMBL17837243 0.64 CDC7 (0.32) BACE1
SCHEMBL612349 0.63 CDC7 (0.54) ABCC8KCNJ11
SCHEMBL246962 0.61 IDO1 (0.56) PDK2PDK4PGRIDO1PDE3B
SCHEMBL31219578 0.60 BCHE (0.47) PDK2PDK4ATAD2PGRIDO1
SCHEMBL755054 0.59 TGM2 (0.53) HTR6IDO1
SCHEMBL16858573 0.59 PGR (0.46) PDK2PDK4ATAD2PGRIDO1
SCHEMBL1233902 0.59 HTR6 (0.40) PDK2PDK4ATAD2PGRHTR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119330982-A Azetidine compound and medical application thereof 中国科学院上海药物研究所 2025-01-21 CN disclosed