Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | BCL9 | O00512 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MYOC | Q99972 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3629791 | 0.84 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1KMT2ABCL9CTNNB1 | |
| SCHEMBL3140495 | 0.83 | SMN1; SMN2 (0.51) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL10569382 | 0.82 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2ABCL9CTNNB1 | |
| SCHEMBL3140991 | 0.77 | PTGS1 (0.53) | SMN1; SMN2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3911244 | 0.77 | MEN1 (0.48) | SMN1; SMN2MEN1KMT2AKDM4ESRD5A2 | |
| SCHEMBL4451964 | 0.76 | MEN1 (0.45) | SMN1; SMN2MEN1KMT2AKDM4ESRD5A2 | |
| SCHEMBL3133551 | 0.76 | MEN1 (0.68) | MEN1KMT2AKDM4ESRD5A2MAPT | |
| SCHEMBL8472108 | 0.75 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL5382529 | 0.74 | PTGS2 (0.49) | SMN1; SMN2MEN1KMT2AKDM4EBCL9 | |
| SCHEMBL3137474 | 0.74 | MEN1 (0.49) | MEN1KMT2AKDM4ESRD5A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2010-01-07 | — | — | US | disclosed |
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | KARO BIO AB (SE) | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090233979-A1 | Indole Derivatives and Their Use as Thyroid Receptor Ligands | TSHR, TRHR, THRA | SMN1; SMN2 4863/4885MEN1 855/4885KMT2A 1408/4885 |
| US-20100004271-A1 | HETEROCYCLIC COMPOUNDS AS AGANIST FOR THE THYROID RECEPTOR | TSHR, GHSR, TRHR | SMN1; SMN2 4757/4885MEN1 496/4885KMT2A 1184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.