Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2204465 | 0.71 | MARK3 (0.61) | — | |
| SCHEMBL14709938 | 0.69 | ALDH1A1 (0.53) | NPC1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL31305738 | 0.68 | NPC1 (0.48) | NPC1KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL30142294 | 0.68 | NPC1 (0.47) | NPC1SMN1; SMN2HPGDMAPTPKM | |
| SCHEMBL30142296 | 0.68 | NPC1 (0.47) | NPC1SMN1; SMN2HPGDMAPTPKM | |
| SCHEMBL18832024 | 0.68 | ALDH1A1 (0.52) | NPC1ALDH1A1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL30622451 | 0.68 | CCR2 (0.53) | NPC1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL2674062 | 0.68 | — | — | |
| SCHEMBL29520454 | 0.67 | NPC1 (0.52) | NPC1KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL6719104 | 0.66 | NPC1 (0.53) | NPC1KDM4EALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735422-A1 | SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF TREATING PHENYLKETONURIA AND OTHER AMINO ACIDURIAS | Sanofi (FR) | 2026-05-06 | — | — | EP | disclosed |
| WO-2025006827-A1 | SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF TREATING PHENYLKETONURIA AND OTHER AMINO ACIDURIAS | GENZYME CORPORATION (US) | 2025-01-02 | — | — | WO | disclosed |