Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.64 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.64 |
| ▸ | TTR | P02766 | 1/20 | 0.54 |
| ▸ | SCD | O00767 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | BCL2 | P10415 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | BAD | Q92934 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23147 | 0.83 | HSD17B1 (0.67) | HSD17B1HSD17B2SCDMEN1KMT2A | |
| SCHEMBL30921 | 0.83 | HSD17B1 (0.73) | HSD17B1HSD17B2SCDMEN1KMT2A | |
| SCHEMBL30222 | 0.82 | HSD17B1 (0.79) | HSD17B1HSD17B2SCDMEN1KMT2A | |
| SCHEMBL31410 | 0.81 | HSD17B1 (0.73) | HSD17B1HSD17B2SCDMEN1KMT2A | |
| SCHEMBL30666 | 0.81 | HSD17B1 (0.59) | HSD17B1HSD17B2SCDMEN1KMT2A | |
| SCHEMBL8402858 | 0.81 | HSD17B1 (0.69) | HSD17B1HSD17B2SCDMEN1KMT2A | |
| SCHEMBL29801 | 0.78 | HSD17B1 (1.00) | HSD17B1HSD17B2TTRBCL2MCL1 | |
| SCHEMBL8404873 | 0.78 | HSD17B1 (0.72) | HSD17B1HSD17B2SCDMEN1KMT2A | |
| SCHEMBL8405370 | 0.78 | HSD17B1 (0.74) | HSD17B1HSD17B2SCDMEN1KMT2A | |
| SCHEMBL8403873 | 0.77 | HSD17B1 (0.67) | HSD17B1HSD17B2SCDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |