SCHEMBL31420654

SCHEMBL31420654

COc1ccc(C[C@@H]2[C@H](OC(=O)NCCBr)[C@@H](OC(=O)OC(C)(C)C)CN2C(=O)OC(C)(C)C)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.39
▸ ALDH1A1 P00352 2/20 0.39
▸ MAPT P10636 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36
▸ TP53 P04637 4/20 0.35
▸ KMT2A Q03164 3/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ GLA P06280 1/20 0.34
▸ THRB P10828 2/20 0.34
▸ MAPK1 P28482 1/20 0.34
▸ CACNA1B Q00975 1/20 0.34
▸ GHSR Q92847 1/20 0.34
▸ CCR3 P51677 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ MMP1 P03956 1/20 0.33
▸ MMP3 P08254 1/20 0.33
▸ MMP7 P09237 1/20 0.33
▸ MMP9 P14780 1/20 0.33
▸ STS P08842 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31420569 0.93 LMNA (0.42) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31421302 0.92 ALDH1A1 (0.40) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31420897 0.91 LMNA (0.41) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31420789 0.91 LMNA (0.39) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31421284 0.90 GHSR (0.40) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31421207 0.90 LMNA (0.38) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31421000 0.89 TDP1 (0.38) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31421005 0.89 CYP2D6 (0.43) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31420830 0.89 LMNA (0.38) LMNAALDH1A1MAPTSMN1; SMN2TP53
SCHEMBL31421163 0.89 LMNA (0.38) LMNAALDH1A1MAPTSMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250129021-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-04-24 — — US disclosed
WO-2025064718-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-03-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250129021-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS MYC, KRAS, NRAS LMNA 3037/4885ALDH1A1 2630/4885MAPT 2071/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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