SCHEMBL31421465

SCHEMBL31421465

COc1ccc(C[C@@H]2[C@H](OC(=O)NCc3cn(-c4cc5ccc(O)cc5oc4=O)nn3)[C@@H](OC(=O)OC(C)(C)C)CN2C(=O)OC(C)(C)C)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PI4KB Q9UBF8 1/20 0.38
▸ AKR1B10 O60218 1/20 0.36
▸ AKR1B1 P15121 1/20 0.36
▸ ESRRB O95718 1/20 0.35
▸ ESRRA P11474 1/20 0.35
▸ APP P05067 2/20 0.34
▸ ADRA1A P35348 1/20 0.34
▸ CA1 P00915 3/20 0.33
▸ CA9 Q16790 3/20 0.33
▸ CA2 P00918 2/20 0.33
▸ CA4 P22748 1/20 0.33
▸ CA7 P43166 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ MAPT P10636 1/20 0.33
▸ MEN1 O00255 2/20 0.32
▸ KMT2A Q03164 2/20 0.32
▸ PKM P14618 1/20 0.32
▸ NPC1 O15118 1/20 0.32
▸ MIF P14174 1/20 0.32
▸ RAB9A P51151 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31420878 0.85 PI4KB (0.34) PI4KBESRRBESRRAADRA1AMIF
SCHEMBL32687422 0.81 ESRRB (0.34) PI4KBESRRBESRRAAPPADRA1A
SCHEMBL31420646 0.79 CYP2D6 (0.45) PI4KBAKR1B10AKR1B1ESRRBESRRA
SCHEMBL32687054 0.78 ESRRB (0.33) PI4KBESRRBESRRAADRA1A
SCHEMBL31421340 0.77 ALDH1A1 (0.38) TP53MAPTMEN1KMT2A
SCHEMBL31420569 0.76 LMNA (0.42) TP53MAPTMEN1KMT2A
SCHEMBL31421246 0.76 LMNA (0.38) TP53MAPTMEN1KMT2A
SCHEMBL31420720 0.75 LMNA (0.44) TP53MAPTMEN1KMT2ANPC1
SCHEMBL31421302 0.75 ALDH1A1 (0.40) TP53MAPTMEN1KMT2A
SCHEMBL31420897 0.74 LMNA (0.41) CA1CA2TP53MAPTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250129021-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-04-24 — — US disclosed
WO-2025064718-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS Interdict Bio, Inc. (US) 2025-03-27 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250129021-A1 SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS MYC, KRAS, NRAS PI4KB 1560/4885AKR1B10 1897/4885AKR1B1 2602/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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