Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.54 |
| ▸ | METAP2 | P50579 | 1/20 | 0.51 |
| ▸ | TCF4 | P15884 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31432030 | 0.86 | POLB (0.46) | FFAR4LMNAALDH1A1KDM4EHPGD | |
| SCHEMBL18332152 | 0.80 | FFAR4 (0.51) | FFAR4CYP2C9METAP2LMNAALDH1A1 | |
| SCHEMBL6432619 | 0.79 | METAP2 (0.76) | FFAR4CYP2C9METAP2TCF4CTNNB1 | |
| SCHEMBL22391857 | 0.79 | CYP2C9 (0.76) | FFAR4CYP2C9TCF4CTNNB1LMNA | |
| SCHEMBL10003032 | 0.79 | FFAR4 (0.48) | FFAR4CYP2C9METAP2LMNAALDH1A1 | |
| SCHEMBL10004439 | 0.78 | ALDH1A1 (0.49) | FFAR4CYP2C9METAP2LMNAALDH1A1 | |
| SCHEMBL18331907 | 0.76 | ALDH1A1 (0.54) | FFAR4CYP2C9METAP2LMNAALDH1A1 | |
| SCHEMBL18570883 | 0.76 | FFAR4 (0.57) | FFAR4CYP2C9METAP2TCF4CTNNB1 | |
| SCHEMBL10003512 | 0.76 | METAP2 (0.47) | FFAR4CYP2C9METAP2LMNAALDH1A1 | |
| SCHEMBL5956125 | 0.75 | ALDH1A1 (0.59) | FFAR4CYP2C9METAP2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025049326-A1 | TRICYCLIC HETEROAROMATIC INHIBITORS OF KLK5 | BIOCRYST PHARMACEUTICALS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |