SCHEMBL31433651

SCHEMBL31433651

Cn1nc(-c2ccc(OCc3ccccc3)nc2OCc2ccccc2)c2cc(F)c(C3=CCN(C[C@H]4CCN(C(=O)OC(C)(C)C)C[C@H]4F)CC3)cc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNF P01375 1/20 0.37
BTK Q06187 1/20 0.35
CCNT1 O60563 4/20 0.35
CDK9 P50750 4/20 0.35
DGAT2 Q96PD7 2/20 0.33
GPR119 Q8TDV5 1/20 0.33
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33
CCNA2 P20248 1/20 0.33
CDK2 P24941 1/20 0.33
CCNA1 P78396 1/20 0.33
CYP2D6 P10635 1/20 0.32
CCR3 P51677 1/20 0.32
JAK1 P23458 1/20 0.31
HTR6 P50406 1/20 0.31
LMNA P02545 1/20 0.31
TP53 P04637 1/20 0.31
PRMT5 O14744 1/20 0.31
PARP1 P09874 1/20 0.31
PARP2 Q9UGN5 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31433618 1.00 TNF (0.37) TNFBTKCCNT1CDK9DGAT2
SCHEMBL31433657 0.95 TNF (0.36) TNFBTKCCNT1CDK9DGAT2
SCHEMBL31433692 0.95 TNF (0.36) TNFBTKCCNT1CDK9DGAT2
SCHEMBL31433811 0.95 TNF (0.36) TNFBTKCCNT1CDK9DGAT2
SCHEMBL31433828 0.91 GPR119 (0.36) BTKCCNT1CDK9DGAT2GPR119
SCHEMBL31433506 0.91 GPR119 (0.36) BTKCCNT1CDK9DGAT2GPR119
SCHEMBL31433844 0.90 CCNT1 (0.34) BTKCCNT1CDK9DGAT2GPR119
SCHEMBL31433862 0.90 CCNT1 (0.34) BTKCCNT1CDK9DGAT2GPR119
SCHEMBL31433950 0.90 CCNT1 (0.34) TNFBTKCCNT1CDK9DGAT2
SCHEMBL31433566 0.90 CCNT1 (0.34) TNFBTKCCNT1CDK9DGAT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050016-A1 TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS Treeline Biosciences, Inc. (US) 2025-03-06 WO disclosed