SCHEMBL31433862

SCHEMBL31433862

Cn1nc(-c2ccc(OCc3ccccc3)nc2OCc2ccccc2)c2ccc(C3=CCN(C[C@H]4CCN(C(=O)OC(C)(C)C)C[C@H]4F)CC3)c(F)c21

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCNT1 O60563 3/20 0.34
CDK9 P50750 3/20 0.34
DGAT2 Q96PD7 2/20 0.34
GPR119 Q8TDV5 1/20 0.33
PRKAB2 O43741 1/20 0.33
PRKAG1 P54619 1/20 0.33
PRKAA2 P54646 1/20 0.33
PRKAA1 Q13131 1/20 0.33
PRKAG3 Q9UGI9 1/20 0.33
PRKAG2 Q9UGJ0 1/20 0.33
PRKAB1 Q9Y478 1/20 0.33
BTK Q06187 1/20 0.33
TP53 P04637 2/20 0.32
CYP2D6 P10635 2/20 0.32
CCR3 P51677 2/20 0.32
CCNA2 P20248 1/20 0.32
CDK2 P24941 1/20 0.32
CCNA1 P78396 1/20 0.32
LMNA P02545 1/20 0.32
PRMT5 O14744 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31433844 1.00 CCNT1 (0.34) CCNT1CDK9DGAT2GPR119PRKAB2
SCHEMBL31433520 0.95 DGAT2 (0.33) CCNT1CDK9DGAT2GPR119PRKAB2
SCHEMBL31433808 0.95 DGAT2 (0.33) CCNT1CDK9DGAT2GPR119PRKAB2
SCHEMBL31433550 0.95 DGAT2 (0.33) CCNT1CDK9DGAT2GPR119PRKAB2
SCHEMBL31433566 0.93 CCNT1 (0.34) CCNT1CDK9DGAT2GPR119BTK
SCHEMBL31433950 0.93 CCNT1 (0.34) CCNT1CDK9DGAT2GPR119BTK
SCHEMBL31433660 0.93 CCNT1 (0.34) CCNT1CDK9DGAT2GPR119BTK
SCHEMBL26925201 0.91 LMNA (0.36) CCNT1CDK9GPR119PRKAB2PRKAG1
SCHEMBL30732082 0.91 LMNA (0.36) CCNT1CDK9GPR119PRKAB2PRKAG1
SCHEMBL31433651 0.90 TNF (0.37) CCNT1CDK9DGAT2GPR119BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050016-A1 TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS Treeline Biosciences, Inc. (US) 2025-03-06 WO disclosed