SCHEMBL31433745

SCHEMBL31433745

C[C@H]1CN(C(=O)OC(C)(C)C)CC[C@H]1CN1CC=C(c2c(F)cc3c(-c4ccc(OCc5ccccc5)nc4OCc4ccccc4)nn(C)c3c2F)CC1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 1/20 0.33
CCNT1 O60563 2/20 0.32
CDK9 P50750 2/20 0.32
DGAT2 Q96PD7 2/20 0.32
TLR9 Q9NR96 2/20 0.32
TLR7 Q9NYK1 2/20 0.32
BTK Q06187 1/20 0.31
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31
CYP2D6 P10635 2/20 0.31
CCR3 P51677 2/20 0.31
CCNA2 P20248 1/20 0.31
CDK2 P24941 1/20 0.31
CCNA1 P78396 1/20 0.31
JAK2 O60674 1/20 0.31
JAK1 P23458 1/20 0.31
PDE10A Q9Y233 1/20 0.31
PRMT5 O14744 3/20 0.31
YAP1 P46937 2/20 0.31
GRM5 P41594 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31433646 1.00 GPR119 (0.33) GPR119CCNT1CDK9DGAT2TLR9
SCHEMBL31433950 0.95 CCNT1 (0.34) GPR119CCNT1CDK9DGAT2TLR9
SCHEMBL31433660 0.95 CCNT1 (0.34) GPR119CCNT1CDK9DGAT2TLR9
SCHEMBL31433566 0.95 CCNT1 (0.34) GPR119CCNT1CDK9DGAT2TLR9
SCHEMBL31433520 0.92 DGAT2 (0.33) GPR119CCNT1CDK9DGAT2BTK
SCHEMBL31433550 0.92 DGAT2 (0.33) GPR119CCNT1CDK9DGAT2BTK
SCHEMBL31433808 0.92 DGAT2 (0.33) GPR119CCNT1CDK9DGAT2BTK
SCHEMBL31433805 0.92 YAP1 (0.36) GPR119CCNT1CDK9TLR9TLR7
SCHEMBL31433811 0.90 TNF (0.36) GPR119CCNT1CDK9DGAT2TLR9
SCHEMBL31434048 0.90 GPR119 (0.35) GPR119CDK9DGAT2TLR9TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025050016-A1 TRICYCLIC QUINOLONE BCL6 BIFUNCTIONAL DEGRADERS Treeline Biosciences, Inc. (US) 2025-03-06 WO disclosed