Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 5/20 | 0.41 |
| ▸ | FPR3 | P25089 | 3/20 | 0.41 |
| ▸ | FPR2 | P25090 | 3/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2144522 | 0.93 | MTNR1A (0.53) | CAMK2DMTNR1AMTNR1BDYRK1ABRD4 | |
| SCHEMBL24542659 | 0.86 | MCL1 (0.52) | CAMK2DDYRK1AFPR3FPR2LMNA | |
| SCHEMBL2144211 | 0.84 | MTNR1A (0.45) | CAMK2DMTNR1AMTNR1BDYRK1ABRD4 | |
| SCHEMBL17690637 | 0.81 | MTNR1A (0.54) | MTNR1AMTNR1BDYRK1ABRD4KDM4E | |
| SCHEMBL15174378 | 0.80 | MAPT (0.57) | DYRK1ABRD4STK17BSTK17ADRD2 | |
| SCHEMBL15175892 | 0.80 | BRD4 (0.54) | BRD4 | |
| SCHEMBL30568519 | 0.79 | DRD2 (0.41) | DYRK1ABRD4STK17BSTK17AKDM4E | |
| SCHEMBL25344128 | 0.79 | DRD2 (0.41) | DYRK1ABRD4STK17BSTK17AKDM4E | |
| SCHEMBL15798230 | 0.78 | DYRK1A (0.56) | CAMK2DDYRK1AFPR3FPR2DRD2 | |
| SCHEMBL25343224 | 0.78 | PRPS1 (0.43) | DYRK1ABRD4STK17BSTK17AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4747260-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025021666-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. HOFFMANN-LA ROCHE AG (CH) | 2025-01-30 | — | — | WO | disclosed |