Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | VDR | P11473 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14185724 | 1.00 | CYP1A2 (0.43) | CYP1A2KDM4EAGTR1LMNACYP2C19 | |
| SCHEMBL13479192 | 0.85 | CYP1A2 (0.43) | CYP1A2KDM4EAGTR1LMNACYP2C19 | |
| SCHEMBL1136671 | 0.75 | HTR2C (0.39) | CA1CA2CA4CA7CA9 | |
| SCHEMBL1136582 | 0.75 | HTR2C (0.39) | CA1CA2CA4CA7CA9 | |
| SCHEMBL1496619 | 0.74 | CYP1A2 (0.64) | CYP1A2KDM4EAGTR1LMNACYP2C19 | |
| SCHEMBL28670310 | 0.74 | CYP1A2 (0.64) | CYP1A2KDM4EAGTR1LMNACYP2C19 | |
| SCHEMBL15067160 | 0.74 | BRD4 (0.50) | PKMHTR6POLB | |
| SCHEMBL19459819 | 0.73 | ALDH1A1 (0.47) | CYP1A2KDM4EAGTR1LMNACYP2C19 | |
| SCHEMBL19459678 | 0.73 | ALDH1A1 (0.47) | CYP1A2KDM4EAGTR1LMNACYP2C19 | |
| SCHEMBL19459952 | 0.73 | ALDH1A1 (0.47) | CYP1A2KDM4EAGTR1LMNACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748995-B1 | ARYLSULFONYL BENZODIOXANES USEFUL FOR MODULATION THE 5-HT6 RECEPTOR, THE 5-HT2ARECEPTOR OR BOTH | HOFFMANN LA ROCHE (CH) | 2010-02-24 | — | — | EP | disclosed |
| US-7368567-B2 | Arylsulfonyl benzodioxanes, benzoxazines and benzothiazines as 5-HT6 antagonists | ROCHE PALO ALTO LLC (US) | 2008-05-06 | — | — | US | disclosed |
| EP-1748995-A1 | ARYLSULFONYL BENZODIOXANES USEFUL FOR MODULATION THE 5-HT6 RECEPTOR, THE 5-HT2ARECEPTOR OR BOTH | F. Hoffmann-La Roche AG (CH) | 2007-02-07 | — | — | EP | disclosed |
| WO-2005105776-A1 | ARYLSULFONYL BENZODIOXANES USEFUL FOR MODULATION THE 5-HT6 RECEPTOR, THE 5-HT2ARECEPTOR OR BOTH | F. HOFFMANN-LA ROCHE AG (CH) | 2005-11-10 | — | — | WO | disclosed |
| US-20050250943-A1 | Arylsulfonyl benzodioxanes, benzoxazines and benzothiazines as 5-HT6 antagonists | ROCHE PALO ALTO LLC | 2005-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050250943-A1 | Arylsulfonyl benzodioxanes, benzoxazines and benzothiazines as 5-HT6 antagonists | HTR6, HTR7, HTR1F | CYP1A2 184/4885KDM4E 1495/4885AGTR1 296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.