Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 12/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9138230 | 0.91 | MAPT (0.68) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| Hydrochloric Acid SCHEMBL16753334 | 0.89 | MAPT (0.66) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| SCHEMBL7706274 | 0.85 | KDM4E (0.55) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| SCHEMBL1682109 | 0.84 | KDM4E (0.54) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| SCHEMBL23217085 | 0.81 | KDM4E (0.55) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| SCHEMBL11807250 | 0.81 | ALDH1A1 (0.57) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| SCHEMBL29530477 | 0.80 | KDM4E (0.81) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| SCHEMBL2638095 | 0.80 | KDM4E (0.81) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| SCHEMBL11139844 | 0.79 | ALDH1A1 (0.49) | MAPTKDM4EALDH1A1CYP2C9ALOX15 | |
| SCHEMBL27428033 | 0.79 | ACHE (0.58) | MAPTKDM4EALDH1A1CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951055-B2 | Thiazole-based inhibitors of scavenger receptor BI | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951055-B2 | Thiazole-based inhibitors of scavenger receptor BI | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2018-04-24 | — | — | US | disclosed |
| US-9951055-B2 | Thiazole-based inhibitors of scavenger receptor BI | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2018-04-24 | — | — | US | disclosed |
| US-20160060254-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | THE BROAD INSTITUTE, INC. | 2016-03-03 | — | — | US | disclosed |
| US-20160060254-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | THE BROAD INSTITUTE, INC. | 2016-03-03 | — | — | US | disclosed |
| US-20160060254-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | THE BROAD INSTITUTE, INC. | 2016-03-03 | — | — | US | disclosed |
| WO-2014063167-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | THE BROAD INSTITUTE, INC. (US) | 2014-04-24 | — | — | WO | disclosed |
| WO-2014063167-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | THE BROAD INSTITUTE, INC. (US) | 2014-04-24 | — | — | WO | disclosed |
| US-20100076049-A1 | NOVEL OXINDOLE DERIVATIVE | THERAVALUES CORPORATION (JP) | 2010-03-25 | — | — | US | disclosed |
| EP-2130829-A1 | NOVEL HYDROXYINDOLE DERIVATIVE | Theravalues Corporation (JP) | 2009-12-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076049-A1 | NOVEL OXINDOLE DERIVATIVE | CYP2C9, HDAC10, SIGMAR1 | MAPT 3912/4885KDM4E 3306/4885ALDH1A1 957/4885 |
| US-20160060254-A1 | THIAZOLE-BASED INHIBITORS OF SCAVENGER RECEPTOR BI | SCARB1, HAVCR2, LDLR | MAPT 4082/4885KDM4E 4719/4885ALDH1A1 1977/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.