Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5611087 | 0.74 | KEAP1 (0.43) | HSP90AA1ALDH1A1KDM4EHPGDMAPT | |
| SCHEMBL10966558 | 0.73 | APOBEC3A (0.50) | NAPRTHSD17B10HSP90AA1HSP90AB1ADORA3 | |
| SCHEMBL2161029 | 0.70 | HSD17B10 (0.48) | NAPRTHSD17B10APOBEC3AAPOBEC3GCYP1A2 | |
| SCHEMBL16051259 | 0.70 | HDAC1 (0.49) | NAPRTHSD17B10HSP90AA1HSP90AB1ADORA3 | |
| SCHEMBL456233 | 0.70 | ESR2 (0.38) | HSD17B10ADORA3ADORA1MAPK1ALDH1A1 | |
| SCHEMBL4371389 | 0.69 | ESR2 (0.41) | HSD17B10MAPK1ALDH1A1HPGDTSHR | |
| SCHEMBL7188387 | 0.69 | MAPT (0.57) | NAPRTHSD17B10CYP1A2ALDH1A1KDM4E | |
| SCHEMBL17205965 | 0.69 | DHODH (0.52) | HSD17B10ADORA3ADORA1APOBEC3AAPOBEC3G | |
| SCHEMBL99181 | 0.68 | ALDH1A1 (0.59) | APOBEC3AAPOBEC3GALDH1A1HDAC1KDM4E | |
| SCHEMBL6662392 | 0.68 | HSD17B10 (0.42) | NAPRTHSD17B10HSP90AA1HSP90AB1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815855-B2 | N-sulphonylpyrroles and their use as histone deacetylase inhibitors | 4SC AG (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20100074862-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | MAIER THOMAS | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100074862-A1 | N-SULPHONYLPYRROLES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS | HDAC1, HDAC3, HDAC2 | NAPRT 231/4885HSD17B10 937/4885HSP90AA1 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.