SCHEMBL31460064

SCHEMBL31460064

Cc1cc2c(Br)nn(COCC[Si](C)(C)C)c2cc1Cl

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 3/20 0.34
NPC1 O15118 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21055191 0.81 DGAT1 (0.36) DGAT1NPC1
SCHEMBL31459935 0.81 KMO (0.37) DGAT1NPC1
SCHEMBL31588698 0.81 DGAT1 (0.37) DGAT1NPC1
SCHEMBL26690074 0.80 DGAT1 (0.36) DGAT1NPC1
SCHEMBL29172538 0.80 NPC1 (0.37) DGAT1NPC1
SCHEMBL21055380 0.80 DGAT1 (0.36) DGAT1NPC1
SCHEMBL31588879 0.76 DGAT1 (0.36) DGAT1NPC1
SCHEMBL16023365 0.76 NPC1 (0.42) DGAT1NPC1
SCHEMBL30706826 0.75 DGAT1 (0.33) DGAT1
SCHEMBL8889178 0.75 ADORA2A (0.41) DGAT1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119677749-A Azaquinazoline pan KRAS inhibitors 米拉蒂治疗股份有限公司 2025-03-21 CN disclosed