Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCB | P05771 | 13/20 | 1.00 |
| ▸ | PRKCA | P17252 | 13/20 | 1.00 |
| ▸ | PRKCG | P05129 | 12/20 | 1.00 |
| ▸ | PRKCE | Q02156 | 12/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 11/20 | 1.00 |
| ▸ | PRKCH | P24723 | 10/20 | 1.00 |
| ▸ | CAMK2D | Q13557 | 10/20 | 1.00 |
| ▸ | CAMK2B | Q13554 | 8/20 | 1.00 |
| ▸ | CAMK2G | Q13555 | 8/20 | 1.00 |
| ▸ | CAMK2A | Q9UQM7 | 8/20 | 1.00 |
| ▸ | PRKCZ | Q05513 | 7/20 | 1.00 |
| ▸ | SRC | P12931 | 3/20 | 0.80 |
| ▸ | GSK3B | P49841 | 5/20 | 0.69 |
| ▸ | CDK2 | P24941 | 2/20 | 0.69 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.69 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.69 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.69 |
| ▸ | STK16 | O75716 | 1/20 | 0.69 |
| ▸ | PAK3 | O75914 | 1/20 | 0.69 |
| ▸ | CDK14 | O94921 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3155547 | 0.99 | PRKCB (0.98) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| SCHEMBL3158797 | 0.89 | PRKCA (1.00) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| SCHEMBL6422277 | 0.89 | PRKCA (1.00) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| SCHEMBL3143669 | 0.88 | PRKCA (1.00) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| SCHEMBL3151388 | 0.88 | PRKCG (0.78) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| Hydrochloric Acid SCHEMBL30958433 | 0.87 | PRKCA (0.98) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| SCHEMBL6423238 | 0.87 | PRKCG (1.00) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| SCHEMBL30958445 | 0.85 | PRKCG (0.78) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| SCHEMBL3155531 | 0.85 | PRKCG (0.78) | PRKCBPRKCAPRKCGPRKCEPRKCD | |
| SCHEMBL30958414 | 0.83 | PRKCG (1.00) | PRKCBPRKCAPRKCGPRKCEPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817627-B1 | PROTEIN KINASE C INHIBITORS | LILLY CO ELI (US) | 2005-03-09 | — | — | EP | claimed |
| EP-1449529-A1 | Protein Kinase C Inhibitors | ELI LILLY AND COMPANY (US) | 2004-08-25 | — | — | EP | claimed |
| US-5668152-A | BIS/INDOLE/-SUBSTITUTED MALEIMIDES, ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-09-16 | — | — | US | claimed |
| EP-1449529-B1 | Protein Kinase C Inhibitors | LILLY CO ELI (US) | 2010-01-27 | — | — | EP | disclosed |
| EP-1449529-A1 | Protein Kinase C Inhibitors | ELI LILLY AND COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| EP-0817627-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5672618-A | TREATING DIABETIC COMPLICATIONS | ELI LILLY AND COMPANY (US) | 1997-09-30 | — | — | US | disclosed |
| US-5668152-A | BIS/INDOLE/-SUBSTITUTED MALEIMIDES, ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| US-5661173-A | ADMINISTERING AN ENZYME INHIBITOR TREATING DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5545636-A | TREATING DIABETES MELLITUS | ELI LILLY AND COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| WO-1995017182-A1 | PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1995-06-29 | — | — | WO | disclosed |