Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL25286323 | 0.86 | PNMT (0.35) | HDAC1HDAC3NAMPTLMNAHDAC6 | |
| Bromide SCHEMBL25242388 | 0.83 | HIF1A (0.38) | — | |
| Hydrochloric Acid SCHEMBL9103546 | 0.73 | RHOC (0.44) | IDO1MEN1KMT2A | |
| SCHEMBL8443819 | 0.73 | IDO1 (0.47) | IDO1MEN1KMT2ALMNAHTT | |
| Bromide SCHEMBL25250392 | 0.72 | SLC7A5 (0.47) | IDO1 | |
| SCHEMBL17777671 | 0.70 | IDO1 (0.50) | IDO1HDAC1HDAC3NAMPTMEN1 | |
| SCHEMBL24461915 | 0.70 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3071899 | 0.70 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24461912 | 0.70 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL24461929 | 0.70 | SMN1; SMN2 (0.47) | MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250042925-A1 | Improved Compositions and Methods for Targeting Mitochondria in Cancer Cells | NATIONAL INSTITUTES OF HEALTH | 2025-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250042925-A1 | Improved Compositions and Methods for Targeting Mitochondria in Cancer Cells | TFAM, UQCRC2, NDUFAB1 | IDO1 4035/4885HDAC1 1091/4885HDAC3 1642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.