Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3152655 | 1.00 | HSD11B1 (0.43) | HSD11B1HPGDALDH1A1USP2KMT2A | |
| SCHEMBL3147106 | 1.00 | HSD11B1 (0.43) | HSD11B1HPGDALDH1A1USP2KMT2A | |
| SCHEMBL6725338 | 1.00 | HSD11B1 (0.43) | HSD11B1HPGDALDH1A1USP2KMT2A | |
| SCHEMBL3152647 | 1.00 | HSD11B1 (0.43) | HSD11B1HPGDALDH1A1USP2KMT2A | |
| SCHEMBL3161094 | 0.97 | HSD11B1 (0.43) | HSD11B1HPGDALDH1A1USP2KMT2A | |
| SCHEMBL8347018 | 0.85 | HPGD (0.39) | HSD11B1HPGDALDH1A1USP2KMT2A | |
| SCHEMBL3147308 | 0.75 | CYP1A2 (0.38) | HSD11B1ALDH1A1USP2 | |
| SCHEMBL21622002 | 0.75 | CYP1A2 (0.38) | HSD11B1ALDH1A1USP2 | |
| SCHEMBL3156153 | 0.75 | CYP1A2 (0.38) | HSD11B1ALDH1A1USP2 | |
| SCHEMBL13450787 | 0.75 | CYP1A2 (0.38) | HSD11B1ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379494-B1 | FUSED BICYCLIC OR TRICYCLIC AMINO ACIDS | WARNER LAMBERT CO (US) | 2010-03-10 | — | — | EP | disclosed |
| US-20040092591-A1 | Therapeutic use of fused bicyclic or tricyclic amino acids | BLAKEMORE DAVID CLIVE (GB) | 2004-05-13 | — | — | US | disclosed |
| US-6596900-B2 | Brain, nervous system, neurodegenerative, gastrointestinal, sleep, rheumatic, and psychological disorders; analgesics, antiepileptic agents | PFIZER INC | 2003-07-22 | — | — | US | disclosed |
| US-20030078300-A1 | Fused bicyclic or tricyclic amino acids | PFIZER INC. | 2003-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030078300-A1 | Fused bicyclic or tricyclic amino acids | AADAT, SLC1A2, BCAT1 | HSD11B1 4544/4885HPGD 3228/4885ALDH1A1 1302/4885 |
| US-20040092591-A1 | Therapeutic use of fused bicyclic or tricyclic amino acids | BCAT1, BCAT2, AADAT | HSD11B1 4124/4885HPGD 1049/4885ALDH1A1 3565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.