SCHEMBL31474086

SCHEMBL31474086

Cc1c(NC(=O)c2ccc3c(c2F)CC(C)(C)C3)cc(F)cc1B1OC(C)(C)C(C)(C)O1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.36
MAPT P10636 1/20 0.36
LIPE Q05469 3/20 0.35
CXCR2 P25025 1/20 0.33
WDR5 P61964 1/20 0.31
GPR35 Q9HC97 1/20 0.31
HPGD P15428 1/20 0.30
TP53 P04637 1/20 0.30
RXFP1 Q9HBX9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31474105 0.85 ALDH1A1 (0.47) ALDH1A1MAPTLIPECXCR2TP53
SCHEMBL31474202 0.85 LIPE (0.34) LIPECXCR2
SCHEMBL31474255 0.85 TP53 (0.38) ALDH1A1MAPTLIPECXCR2HPGD
SCHEMBL31474075 0.82 LIPE (0.35) ALDH1A1MAPTLIPECXCR2HPGD
SCHEMBL31474067 0.81 LIPE (0.34) ALDH1A1MAPTLIPECXCR2
SCHEMBL31473986 0.80 NPC1 (0.32) ALDH1A1MAPTCXCR2RXFP1
SCHEMBL27003891 0.79 LIPE (0.39) LIPECXCR2
SCHEMBL31473998 0.77 LIPE (0.36) ALDH1A1MAPTLIPECXCR2
SCHEMBL29520132 0.77 BTK (0.45)
SCHEMBL16754856 0.77 BTK (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025061148-A1 HETEROARYL COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE 江苏恒瑞医药股份有限公司 2025-03-27 WO disclosed