Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 4/20 | 0.49 |
| ▸ | HTR1A | P08908 | 15/20 | 0.44 |
| ▸ | HTR1D | P28221 | 15/20 | 0.44 |
| ▸ | HTR1B | P28222 | 13/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13525140 | 1.00 | CYP2C9 (0.49) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL3137750 | 0.84 | CYP2C9 (0.50) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL10516997 | 0.76 | NCF1 (0.65) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL2881010 | 0.76 | CYP2C9 (0.50) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL4180251 | 0.76 | CYP2C9 (0.50) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL429083 | 0.76 | CYP2C9 (0.50) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL428165 | 0.75 | NCF1 (0.69) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL6622483 | 0.74 | HTR1A (0.53) | HTR1AHTR1DHTR1BPTPN11NCF1 | |
| SCHEMBL6066286 | 0.74 | CYP2C9 (0.60) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL13525141 | 0.74 | CYP2C9 (0.67) | CYP2C9HTR1AHTR1DHTR1BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004452-A1 | 5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC. | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | disclosed |
| US-20100004452-A1 | 5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC. | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | disclosed |
| US-20100004452-A1 | 5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC. | GLAXO GROUP LIMITED (GB) | 2010-01-07 | — | — | US | disclosed |
| WO-2008037681-A1 | 5-{2-[4-(2-METHYL-5-QUINOLINYL)-L-PIPERIDINYL] ETHYL} QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIREMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC. | GLAXO GROUP LIMITED (GB) | 2008-04-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004452-A1 | 5-QUINOLINONE DERIVATIVES AS 5HT1A RECEPTOR MODULATORS FOR TREATING SEXUAL DYSFUNCTION, COGNITION IMPAIRMENT, PSYCHOTIC DISORDERS, ANXIETY, DEPRESSION, ETC. | HTR1A, HTR1D, HTR1E | CYP2C9 1277/4885HTR1A 1/4885HTR1D 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.