Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | PKM | P14618 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | METAP1 | P53582 | 2/20 | 0.45 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 3/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | KRAS | P01116 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9452004 | 0.85 | PDE3B (0.42) | ALDH1A1PKMKDM4EMETAP2PDE3B | |
| SCHEMBL14629339 | 0.81 | PSMB8 (0.53) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 | |
| SCHEMBL222527 | 0.75 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 | |
| SCHEMBL1170780 | 0.74 | ALDH1A1 (0.68) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 | |
| SCHEMBL34462940 | 0.71 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 | |
| SCHEMBL21496798 | 0.71 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 | |
| SCHEMBL2106050 | 0.71 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 | |
| SCHEMBL15088513 | 0.71 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 | |
| SCHEMBL9698797 | 0.71 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 | |
| SCHEMBL7249651 | 0.71 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2PKMKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233493-A1 | Macrolides | Pfizer Products Inc. (US) | 2010-09-29 | — | — | EP | disclosed |
| EP-1836211-B1 | MACROLIDES | PFIZER PROD INC (US) | 2010-03-03 | — | — | EP | disclosed |