Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | DAO | P14920 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 8/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147724 | 0.85 | ALDH1A1 (0.46) | PDE3BPDE3AKDM4EMETAP2ALDH1A1 | |
| SCHEMBL14427087 | 0.81 | PSMB8 (0.49) | PDE3BPDE3ADAOACHEKDM5A | |
| SCHEMBL4448533 | 0.75 | ALDH1A1 (0.42) | PDE3BPDE3ADAOACHEPARP1 | |
| SCHEMBL222527 | 0.75 | ALDH1A1 (0.54) | KDM4EALDH1A1PKM | |
| SCHEMBL2143546 | 0.71 | ALDH1A1 (0.44) | PDE3BPDE3ADAOACHEKDM4C | |
| SCHEMBL4059259 | 0.71 | NUDT1 (0.55) | PDE3BPDE3ADAOACHEMAPT | |
| SCHEMBL30678618 | 0.71 | NUDT1 (0.55) | PDE3BPDE3ADAOACHEMAPT | |
| SCHEMBL3987647 | 0.71 | PDE3B (0.41) | PDE3BPDE3ADAOACHEPARP1 | |
| SCHEMBL17950072 | 0.71 | PDE3B (0.41) | PDE3BPDE3ADAOACHEPARP1 | |
| SCHEMBL562793 | 0.71 | DAO (0.44) | PDE3BPDE3ADAOACHEPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5229386-A | Anticoagulants, hypotensive agents, antiallergens, antiinflammatory agents | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-20 | — | — | US | disclosed |
| US-5145860-A | Anticoagulants, vasodilators, antiinflammatory, antiallergens, enzyme inhibitors | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-09-08 | — | — | US | disclosed |
| EP-0388909-A2 | Thiazole compounds, processes for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1990-09-26 | — | — | EP | disclosed |