SCHEMBL31479050

SCHEMBL31479050

CCN(C(=O)c1cc(F)ccc1-c1cc(N2CCN(C(=O)[C@@H]3[C@H]4CC[C@H](C4)N3C(=O)OC(C)(C)C)CC2)cn2cncc12)C(C)C

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PREP P48147 4/20 0.41
MAPT P10636 1/20 0.32
GPR119 Q8TDV5 4/20 0.31
MEN1 O00255 2/20 0.31
KMT2A Q03164 2/20 0.31
KCNH2 Q12809 1/20 0.31
JAK1 P23458 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31479920 0.88 PREP (0.40) PREPGPR119JAK1
SCHEMBL31479996 0.88 GPR119 (0.37) MAPTGPR119MEN1KMT2A
SCHEMBL31479531 0.87 PREP (0.37) PREPMEN1KMT2AKCNH2JAK1
SCHEMBL31479113 0.87 PREP (0.37) PREPGPR119MEN1KMT2AKCNH2
SCHEMBL31479706 0.86 PREP (0.38) PREPMAPTGPR119MEN1KMT2A
SCHEMBL31479380 0.85 PREP (0.38) PREPMAPTGPR119MEN1KMT2A
SCHEMBL31478971 0.84 PREP (0.37) PREPMAPTGPR119MEN1KMT2A
SCHEMBL31478999 0.84 PREP (0.40) PREPMAPTGPR119MEN1KMT2A
SCHEMBL31479282 0.83 PREP (0.38) PREPMAPTGPR119
SCHEMBL31478957 0.80 SUV39H2 (0.37) MEN1KMT2AKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025067111-A1 MENIN-MLL INTERACTION INHIBITOR AND PREPARATION METHOD THEREFOR, AND APPLICATION 苏州必扬医药科技有限公司 2025-04-03 WO disclosed