SCHEMBL31480481

SCHEMBL31480481

COC(=O)c1ccc(C2CC3(CCN2)CC(F)(F)C3)c(N)n1

nearest known ligand 0.30

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.30
CRBN Q96SW2 1/20 0.30
CNR1 P21554 1/20 0.30
CNR2 P34972 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31480488 0.85 MAPT (0.31) MAPT
SCHEMBL31480146 0.84 CRBN (0.34) CRBNCNR2
SCHEMBL31480574 0.84 SCN9A (0.31)
SCHEMBL31480086 0.84
SCHEMBL31480606 0.83 CRBN (0.33) CRBN
SCHEMBL31480318 0.82 MAPK1 (0.33) CRBNCNR2
SCHEMBL31480450 0.82
SCHEMBL31480165 0.80 GABRA1 (0.33) MAPT
SCHEMBL31561368 0.80 MAPK1 (0.40) MAPT
SCHEMBL31140832 0.80 MAPK1 (0.40) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025054361-A1 COMPLEMENT INHIBITION APELLIS PHARMACEUTICALS, INC. (US) 2025-03-13 WO disclosed