Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 19/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.66 |
| ▸ | PTAFR | P25105 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487455 | 1.00 | TACR1 (0.88) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL2487457 | 1.00 | TACR1 (0.88) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL13627550 | 0.92 | TACR1 (1.00) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL13627555 | 0.92 | TACR1 (1.00) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL13451567 | 0.92 | TACR1 (1.00) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL13627551 | 0.92 | TACR1 (1.00) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL13627549 | 0.91 | TACR1 (0.98) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL13627577 | 0.91 | TACR1 (0.98) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL13627548 | 0.91 | TACR1 (0.98) | TACR1CYP3A4SIGMAR1PTAFR | |
| SCHEMBL13627584 | 0.91 | TACR1 (0.98) | TACR1CYP3A4SIGMAR1PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1921064-B1 | Pharmaceutical composition | GLAXO GROUP LTD (GB) | 2010-05-19 | — | — | EP | disclosed |
| US-20100081667-A1 | Chemical Compounds | ALVARO GIUSEPPE | 2010-04-01 | — | — | US | disclosed |
| US-7648990-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2010-01-19 | — | — | US | disclosed |
| EP-1921064-A1 | Pharmaceutical composition | GLAXO GROUP LIMITED (GB) | 2008-05-14 | — | — | EP | disclosed |
| US-20080021041-A1 | Chemical Compounds | GLAXO GROUP LIMITED (GB) | 2008-01-24 | — | — | US | disclosed |
| US-7294630-B2 | Piperazinyl piperidine tachykinin antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-13 | — | — | US | disclosed |
| EP-1524266-B1 | Pharmaceutical composition | GLAXO GROUP LTD (GB) | 2007-02-28 | — | — | EP | disclosed |
| EP-1752449-A1 | Pharmaceutical coposition | GLAXO GROUP LIMITED (GB) | 2007-02-14 | — | — | EP | disclosed |
| US-7119092-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-10 | — | — | US | disclosed |
| US-20060142302-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2006-06-29 | — | — | US | disclosed |
| US-7060702-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2006-06-13 | — | — | US | disclosed |
| US-20050137208-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2005-06-23 | — | — | US | disclosed |
| EP-1326832-B1 | CHEMICAL COMPOUNDS | GLAXO GROUP LTD (GB) | 2004-10-06 | — | — | EP | disclosed |
| US-20040014770-A1 | Chemical compounds | GLAXO GROUP LIMITED (GB) | 2004-01-22 | — | — | US | disclosed |
| EP-1326832-A1 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002032867-A1 | CHEMICAL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2002-04-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080021041-A1 | Chemical Compounds | OPRL1, OPRK1, OPRM1 | TACR1 53/4885CYP3A4 141/4885SIGMAR1 98/4885 |
| US-20050137208-A1 | Chemical compounds | TACR2, TAC3, MC2R | TACR1 5/4885CYP3A4 515/4885SIGMAR1 328/4885 |
| US-20040014770-A1 | Chemical compounds | HCK, KCNK4, GRK4 | TACR1 188/4885CYP3A4 148/4885SIGMAR1 434/4885 |
| US-20060142302-A1 | Chemical compounds | TACR2, TAC3, MC2R | TACR1 5/4885CYP3A4 515/4885SIGMAR1 328/4885 |
| US-20100081667-A1 | Chemical Compounds | OPRL1, OPRK1, OPRM1 | TACR1 53/4885CYP3A4 141/4885SIGMAR1 98/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.