Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2953994 | 0.97 | ACHE (0.54) | ACHEMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL7971275 | 0.88 | ACHE (0.48) | ACHEMEN1KMT2AALDH1A1PSEN1 | |
| SCHEMBL5310614 | 0.87 | PSEN1 (0.59) | ACHEMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL2964063 | 0.87 | PSEN1 (0.43) | ACHEMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL8320723 | 0.87 | PSEN1 (0.43) | ACHEMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL8327363 | 0.86 | MMP2 (0.48) | ALDH1A1PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8319711 | 0.85 | ALDH1A1 (0.58) | MEN1KMT2APOLBALDH1A1PSEN1 | |
| SCHEMBL2969335 | 0.85 | ALDH1A1 (0.58) | MEN1KMT2APOLBALDH1A1PSEN1 | |
| SCHEMBL2969395 | 0.84 | TDP1 (0.41) | ACHEMEN1KMT2APOLBALDH1A1 | |
| SCHEMBL8320747 | 0.84 | TDP1 (0.41) | ACHEMEN1KMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585728-B1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-02-24 | — | — | EP | claimed |
| CN-102887853-B | A kind of preparation method of trandolapril intermediate | SHANGHAI JIAO TONG UNIVERSITY (CN) | 2016-01-13 | — | — | CN | disclosed |
| CN-102887853-A | Method for preparing trandolapril intermediate | UNIV SHANGHAI JIAOTONG | 2013-01-23 | — | — | CN | disclosed |