SCHEMBL31483093

SCHEMBL31483093

COc1cc(-c2ccn3nc(N)cc3n2)cnc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 20/20 1.00
PIK3CA P42336 17/20 1.00
PIK3CD O00329 14/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483058 0.80 PIK3CD (0.71) PIK3CGPIK3CAPIK3CD
SCHEMBL31483001 0.78 PIK3CG (0.63) PIK3CGPIK3CAPIK3CD
SCHEMBL30975226 0.77 PIK3CG (0.62) PIK3CGPIK3CAPIK3CD
SCHEMBL31483039 0.76 PIK3CA (0.61) PIK3CGPIK3CAPIK3CD
SCHEMBL31483065 0.69 PIK3CD (0.53) PIK3CGPIK3CAPIK3CD
SCHEMBL30827994 0.69 PIK3CG (0.52) PIK3CGPIK3CAPIK3CD
SCHEMBL31483046 0.68 PIK3CD (0.53) PIK3CGPIK3CAPIK3CD
SCHEMBL15345160 0.66 CYP2A6 (0.51) PIK3CGPIK3CAPIK3CD
SCHEMBL31483021 0.66 PIK3CA (0.49) PIK3CGPIK3CAPIK3CD
SCHEMBL7065894 0.65 PIK3CG (0.46) PIK3CGPIK3CAPIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed