SCHEMBL31484133

SCHEMBL31484133

Cc1cc(C)c(Nc2cc(C#N)nc(Cl)n2)c(C)c1

nearest known ligand 0.43

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 18/20 0.41
KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31484173 0.87 KDM4E (0.40) KDM4E
SCHEMBL31484171 0.83 MAPT (0.39) RAPGEF4KDM4E
SCHEMBL31484251 0.79 GAA (0.43) RAPGEF4KDM4E
SCHEMBL1183306 0.79 RAPGEF4 (0.48) RAPGEF4
SCHEMBL31484144 0.79 NPSR1 (0.47) KDM4E
SCHEMBL31484197 0.77 SLC2A1 (0.47) KDM4E
SCHEMBL1183435 0.76 RAPGEF4 (0.45) RAPGEF4
SCHEMBL31484220 0.75 NFKB1 (0.56)
SCHEMBL31484148 0.74 NUDT1 (0.49) RAPGEF4KDM4E
SCHEMBL31484139 0.74 KDM4E (0.47) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119431324-A 1- (4/5-Cyano-6-substituted pyrimidine-2-yl) -1H-pyrazole-4-formic acid compound, and preparation method and application thereof 沈阳药科大学 2025-02-14 CN disclosed