Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298054 | 1.00 | MAPK1 (0.41) | MAPK1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL1297403 | 0.91 | BTK (0.43) | MAPK1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL6160832 | 0.91 | DGAT1 (0.41) | MAPK1CHRM2CHRM1CHRM3DGAT1 | |
| SCHEMBL1297008 | 0.91 | BTK (0.43) | MAPK1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL25286574 | 0.91 | BTK (0.43) | MAPK1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL25245251 | 0.91 | BTK (0.43) | MAPK1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL6162465 | 0.91 | BTK (0.43) | MAPK1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL6159675 | 0.91 | DGAT1 (0.41) | MAPK1CHRM2CHRM1CHRM3DGAT1 | |
| SCHEMBL6159678 | 0.91 | DGAT1 (0.41) | MAPK1CHRM2CHRM1CHRM3DGAT1 | |
| SCHEMBL28741145 | 0.91 | MAPK1 (0.37) | MAPK1CHRM2CHRM1CHRM3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1731499-B1 | PROCESS FOR PRODUCING 1,2-CIS-2-FLUOROCYCLOPROPANE-1-CARBOXYLIC ESTER COMPOUND | DAIICHI SANKYO CO LTD (JP) | 2014-10-01 | — | — | EP | disclosed |
| US-7847041-B2 | Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-12-07 | — | — | US | disclosed |
| US-7847041-B2 | Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-12-07 | — | — | US | disclosed |
| US-7847041-B2 | Cobalt-catalyzed asymmetric cyclopropanation of electron-deficient olefins | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-12-07 | — | — | US | disclosed |
| US-20100076239-A1 | ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS WITH DIAZO REAGENTS | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100076239-A1 | ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS WITH DIAZO REAGENTS | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100076239-A1 | ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS WITH DIAZO REAGENTS | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-03-25 | — | — | US | disclosed |
| US-20090069519-A1 | COBALT-CATALYZED ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS | NATIONAL SCIENCE FOUNDATION | 2009-03-12 | — | — | US | disclosed |
| US-20090069519-A1 | COBALT-CATALYZED ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS | NATIONAL SCIENCE FOUNDATION | 2009-03-12 | — | — | US | disclosed |
| US-20090069519-A1 | COBALT-CATALYZED ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS | NATIONAL SCIENCE FOUNDATION | 2009-03-12 | — | — | US | disclosed |
| US-7381833-B2 | Process for producing 1,2-cis-2-fluorocyclopropane-1-carboxylic ester compound | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2008-06-03 | — | — | US | disclosed |
| US-20070191626-A1 | Process for producing 1,2-cis-2 fluorocyclopropane- 1carboxylic ester compound | DAIICHI PHARMACEUTICAL CO., LTD (JP) | 2007-08-16 | — | — | US | disclosed |
| EP-1731499-A1 | PROCESS FOR PRODUCING 1,2-CIS-2-FLUOROCYCLOPROPANE-1CARBOXYLIC ESTER COMPOUND | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2006-12-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191626-A1 | Process for producing 1,2-cis-2 fluorocyclopropane- 1carboxylic ester compound | HACL2, B2M, CA1 | MAPK1 1093/4885CHRM2 18/4885CHRM1 19/4885 |
| US-20100076239-A1 | ASYMMETRIC CYCLOPROPANATION OF ELECTRON-DEFICIENT OLEFINS WITH DIAZO REAGENTS | DUOX2, DUOX1, PPOX | MAPK1 4216/4885CHRM2 3109/4885CHRM1 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.