SCHEMBL31488043

SCHEMBL31488043

O=C(OC1CC1)N1CCC(c2cnn3cc(OS(=O)(=O)C(F)(F)F)cnc23)CC1

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ GPR119 Q8TDV5 10/20 0.34
▸ HRH3 Q9Y5N1 8/20 0.33
▸ ADAM10 O14672 1/20 0.32
▸ MMP2 P08253 1/20 0.32
▸ MMP8 P22894 1/20 0.32
▸ MMP12 P39900 1/20 0.32
▸ ADAM17 P78536 1/20 0.32
▸ TLR9 Q9NR96 1/20 0.32
▸ TLR8 Q9NR97 1/20 0.32
▸ TLR7 Q9NYK1 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31487816 0.87 GPR119 (0.45) GPR119
SCHEMBL31487845 0.74 MET (0.37) GPR119HRH3TLR9TLR8TLR7
SCHEMBL31487550 0.72 USP30 (0.40) GPR119HRH3TLR9TLR8TLR7
SCHEMBL31487869 0.72 GPR119 (0.44) GPR119
SCHEMBL31487807 0.71 GPR119 (0.44) GPR119TLR9TLR8TLR7
SCHEMBL31487820 0.69 RET (0.47) GPR119
SCHEMBL31487963 0.69 PIK3R1 (0.33) GPR119
SCHEMBL31487760 0.68 GPR119 (0.47) GPR119
SCHEMBL31487766 0.67 GPR119 (0.48) GPR119TLR9TLR8TLR7
SCHEMBL31487843 0.65 RET (0.55) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025089370-A1 COMPOUNDS AS CSF1R INHIBITORS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2025-05-01 — — WO disclosed
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