Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | AR | P10275 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28411789 | 0.90 | ALDH1A1 (0.52) | SIGMAR1KDM4EALDH1A1ARLMNA | |
| SCHEMBL3143293 | 0.87 | LMNA (0.54) | SIGMAR1HRH3KDM4EALDH1A1TDP1 | |
| SCHEMBL3157089 | 0.85 | LMNA (0.56) | SIGMAR1HRH3KDM4EALDH1A1TDP1 | |
| SCHEMBL3152747 | 0.82 | ALDH1A1 (0.58) | SIGMAR1ALDH1A1ARLMNAHTR1A | |
| SCHEMBL3158281 | 0.81 | SIGMAR1 (0.46) | SIGMAR1ALDH1A1LMNAOPRK1 | |
| SCHEMBL14174854 | 0.81 | KMT2A (0.52) | HRH3ALDH1A1LMNA | |
| Water SCHEMBL11239433 | 0.80 | ALDH1A1 (0.42) | HRH3ALDH1A1LMNA | |
| Water SCHEMBL11239429 | 0.80 | ALDH1A1 (0.42) | HRH3ALDH1A1LMNA | |
| SCHEMBL3573746 | 0.79 | SIGMAR1 (0.64) | SIGMAR1HRH3KDM4EALDH1A1TDP1 | |
| SCHEMBL1361808 | 0.78 | ALDH1A1 (0.50) | SIGMAR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1224170-B9 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2017-11-22 | — | — | EP | disclosed |
| EP-2157081-A1 | Indolinones substituted in six locations, their manufacture and their application as medicine | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2010-02-24 | — | — | EP | disclosed |
| EP-1224170-B1 | 6-POSITION SUBSTITUTED INDOLINE, PRODUCTION AND USE THEREOF AS A MEDICAMENT | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-08-12 | — | — | EP | disclosed |
| US-6762180-B1 | Substituted indolines which inhibit receptor tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-07-13 | — | — | US | disclosed |
| CN-1391557-A | 6-substituted indolinones, their preparation and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-15 | — | — | CN | disclosed |