SCHEMBL3149399

SCHEMBL3149399

CC1=Cc2c(-c3cccc4ccccc34)cccc2C1[Si](C)(C)C1C(C)=Cc2c(-c3cccc4ccccc34)cccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP3 O14638 1/20 0.38
ENPP1 P22413 1/20 0.38
DHFR P00374 1/20 0.36
MAPT P10636 3/20 0.36
ALOX15 P16050 3/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
KDM4E B2RXH2 5/20 0.35
ALDH1A1 P00352 5/20 0.35
HPGD P15428 4/20 0.35
MAPK1 P28482 2/20 0.35
L3MBTL1 Q9Y468 2/20 0.35
TDP2 O95551 1/20 0.35
ALOX12 P18054 1/20 0.35
CASP3 P42574 1/20 0.35
HTT P42858 1/20 0.35
GALK1 P51570 1/20 0.35
BLM P54132 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5167145 0.97 ENPP3 (0.36) ENPP3ENPP1DHFRMAPTALOX15
SCHEMBL1452672 0.92 ENPP3 (0.33) ENPP3ENPP1DHFRMAPTALOX15
SCHEMBL7054875 0.91 ENPP3 (0.38) ENPP3ENPP1DHFRMAPTALOX15
SCHEMBL7783130 0.89 ENPP3 (0.32) ENPP3ENPP1DHFRMAPTALOX15
SCHEMBL7783128 0.89 ENPP3 (0.32) ENPP3ENPP1DHFRMAPTALOX15
SCHEMBL7053238 0.89 ENPP3 (0.36) ENPP3ENPP1DHFRMAPTALOX15
SCHEMBL4466994 0.89 ENPP3 (0.36) ENPP3ENPP1DHFRMAPTALOX15
SCHEMBL3144749 0.87 ALDH1A1 (0.37) ENPP3ENPP1MAPTKDM4EALDH1A1
SCHEMBL14448393 0.87 CA12 (0.32) ENPP3ENPP1KDM4EALDH1A1HPGD
SCHEMBL5836057 0.86 ENPP3 (0.35) ENPP3ENPP1DHFRMAPTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1270614-B1 Copolymers containing propylene and alpha-olefin comonomer BASELL POLYOLEFINE GMBH (DE) 2010-01-27 EP disclosed
US-7241903-B2 Metallocenes, use in catalyst system for producing olefin polymers BASELL POLYOLEFINE GMBH (DE) 2007-07-10 US disclosed
EP-1397371-B1 METALLOCENES AND THEIR USE IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS BASELL POLYOLEFINE GMBH (DE) 2006-03-22 EP disclosed
US-6984743-B1 Method for producing metallocenes BASELL POLYOLEFINE GMBH (DE) 2006-01-10 US disclosed
US-6787618-B1 TRANSPARENT, STIFF MOLDING MATERIALS; IMPACT TOUGHNESS; FOOD PACKAGING BASELL POLYPROPYLEN GMBH (DE) 2004-09-07 US disclosed
US-20040171855-A1 Metallocenes, use in catalyst system for producing olefin polymers EQUISTAR CHEMICALS, LP 2004-09-02 US disclosed
EP-1397371-A1 METALLOCENES AND THEIR USE IN CATALYST SYSTEMS FOR PRODUCING OLEFIN POLYMERS Basell Polyolefine GmbH (DE) 2004-03-17 EP disclosed
EP-0776913-B1 High molecular weight copolymers BASELL POLYOLEFINE GMBH (DE) 2004-02-04 EP disclosed
US-6620953-B1 Complexing dimethylbis(2-methyl-4,5-benzoindenyl)silane with transition metal compounds such as 2,4-di-tert-butylphenoxide, zirconium monochloride, to form polymerization catalysts BASSELL POLYOLEFINE GMBH (DE) 2003-09-16 US disclosed
EP-0985674-B1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR ALPHA-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING ALPHA-OLEFIN POLYMERS MITSUBISHI CHEM CORP (JP) 2003-04-23 EP disclosed
US-6057408-A CATALYTIC ADDITION COPOLYMERIZATION OF PROPYLENE WITH ETHYLENE OR OLEFIN TARGOR GMBH (DE) 2000-05-02 US disclosed
US-6051727-A A POLYMERIZATION CATALYST FOR POLYOLEFINS OF HIGH MOLECULAR WEIGHT, OF PARTICULAR IMPORTANCE FOR THE PRODUCTION OF FILMS, SHEETS OR LARGE HOLLOW ARTICLES OR MOLDINGS SUCH AS PIPES TARGOR GMBH (DE) 2000-04-18 US disclosed
EP-0985674-A1 ORGANIC COMPOUNDS CONTAINING SILICON OR GERMANIUM, TRANSITION METAL COMPLEXES, CATALYST FOR $g(a)-OLEFIN POLYMERIZATION, AND PROCESSES FOR PRODUCING $g(a)-OLEFIN POLYMERS MITSUBISHI CHEMICAL CORPORATION (JP) 2000-03-15 EP disclosed
US-5840644-A OLEFIN POLYMERIZATION CATALYSTS TARGOR GMBH (DE) 1998-11-24 US disclosed
US-5786432-A POLYMERIZING OR COPOLYMERIZING OLEFIN IN PRESENCE OF TRANSITION METAL METALLOCENE CATALYST AND COCATALYST TARGOR GMBH (DE) 1998-07-28 US disclosed
US-5770753-A ADDITION POLYMERIZATION CATALYST TARGOR GMBH (DE) 1998-06-23 US disclosed
EP-0576970-B1 Metallocenes with arylsubstituted indenyl-derivatives as ligands, process for their preparation and their use as catalysts HOECHST AG (DE) 1998-01-14 EP disclosed
EP-0790076-A2 Catalysts containing metallocenes with arylsubstituted indenyl derivatives as ligands, process and intermediates for the preparation of these metallocenes and their use HOECHST AKTIENGESELLSCHAFT (DE) 1997-08-20 EP disclosed
EP-0776913-A2 High molecular weight copolymers HOECHST AKTIENGESELLSCHAFT (DE) 1997-06-04 EP disclosed
EP-0576970-A1 Metallocenes with arylsubstituted indenyl-derivatives as ligands, process for their preparation and their use as catalysts HOECHST AKTIENGESELLSCHAFT (DE) 1994-01-05 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040171855-A1 Metallocenes, use in catalyst system for producing olefin polymers H1-4, H1-0, H1-10 ENPP3 4569/4885ENPP1 4736/4885DHFR 3388/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.