SCHEMBL3144749

SCHEMBL3144749

CC1=Cc2c(-c3cc4ccccc4c4ccccc34)cccc2C1[Si](C)(C)C1C(C)=Cc2c(-c3cc4ccccc4c4ccccc34)cccc21

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.37
HPGD P15428 3/20 0.37
HSD17B10 Q99714 2/20 0.37
MAPK1 P28482 2/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
TSHR P16473 1/20 0.37
CASP1 P29466 1/20 0.37
HIF1A Q16665 1/20 0.37
CYP11B1 P15538 1/20 0.33
CYP1A2 P05177 1/20 0.33
NISCH Q9Y2I1 1/20 0.32
MAOA P21397 1/20 0.31
MAOB P27338 1/20 0.31
KDM4E B2RXH2 1/20 0.31
TDP2 O95551 1/20 0.31
MAPT P10636 1/20 0.31
ALOX12 P18054 1/20 0.31
CASP3 P42574 1/20 0.31
HTT P42858 1/20 0.31
GALK1 P51570 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5168428 0.97 ALDH1A1 (0.36) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL3149399 0.87 ENPP3 (0.38) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
Hydrochloric Acid SCHEMBL5167145 0.85 ENPP3 (0.36) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL1452672 0.81 ENPP3 (0.33) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL5836701 0.80 RAB9A (0.37) ALDH1A1HPGDHSD17B10MAPK1TSHR
Hydrochloric Acid SCHEMBL8674061 0.80 ALDH1A1 (0.38) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL7054875 0.79 ENPP3 (0.38) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL7946244 0.78 ALDH1A1 (0.31) ALDH1A1HPGDHSD17B10MAPK1L3MBTL1
SCHEMBL14448393 0.78 CA12 (0.32) ALDH1A1HPGDHSD17B10MAOAMAOB
SCHEMBL3159292 0.78 GSTP1 (0.38) ALDH1A1HPGDHSD17B10TSHRCYP11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1270614-B1 Copolymers containing propylene and alpha-olefin comonomer BASELL POLYOLEFINE GMBH (DE) 2010-01-27 EP disclosed
US-6787618-B1 TRANSPARENT, STIFF MOLDING MATERIALS; IMPACT TOUGHNESS; FOOD PACKAGING BASELL POLYPROPYLEN GMBH (DE) 2004-09-07 US disclosed
EP-0776913-B1 High molecular weight copolymers BASELL POLYOLEFINE GMBH (DE) 2004-02-04 EP disclosed
EP-1270614-A2 Copolymers containing propylene and alpha-olefin comonomer Basell Polyolefine GmbH (DE) 2003-01-02 EP disclosed
US-6057408-A CATALYTIC ADDITION COPOLYMERIZATION OF PROPYLENE WITH ETHYLENE OR OLEFIN TARGOR GMBH (DE) 2000-05-02 US disclosed
EP-0776913-A2 High molecular weight copolymers HOECHST AKTIENGESELLSCHAFT (DE) 1997-06-04 EP disclosed