Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | HPGD | P15428 | 6/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GALK1 | P51570 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3149399 | 0.97 | ENPP3 (0.38) | ENPP3ENPP1DHFRMAPTSMN1; SMN2 | |
| SCHEMBL1452672 | 0.90 | ENPP3 (0.33) | ENPP3ENPP1DHFRMAPTSMN1; SMN2 | |
| SCHEMBL7054875 | 0.89 | ENPP3 (0.38) | ENPP3ENPP1DHFRMAPTSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL5168428 | 0.88 | ALDH1A1 (0.36) | ALDH1A1HPGDMAPK1L3MBTL1HSD17B10 | |
| SCHEMBL7783130 | 0.86 | ENPP3 (0.32) | ENPP3ENPP1DHFRMAPTSMN1; SMN2 | |
| SCHEMBL7783128 | 0.86 | ENPP3 (0.32) | ENPP3ENPP1DHFRMAPTSMN1; SMN2 | |
| SCHEMBL4466994 | 0.86 | ENPP3 (0.36) | ENPP3ENPP1DHFRMAPTSMN1; SMN2 | |
| SCHEMBL7053238 | 0.86 | ENPP3 (0.36) | ENPP3ENPP1DHFRMAPTSMN1; SMN2 | |
| SCHEMBL3144749 | 0.85 | ALDH1A1 (0.37) | ENPP3ENPP1MAPTKDM4EALDH1A1 | |
| SCHEMBL14448393 | 0.84 | CA12 (0.32) | ENPP3ENPP1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247686-B2 | Solid cocatalyst component for olefin polymerization and catalyst system thereof | BASELL POLYOLEFINE GMBH (DE) | 2007-07-24 | — | — | US | disclosed |
| EP-1442067-B1 | SOLID COCATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST SYSTEM THEREOF | SUNALLOMER LTD (JP) | 2007-04-18 | — | — | EP | disclosed |
| US-20050009689-A1 | Solid cocatalyst component for olefin polymerization and catalyst system thereof | SUNALLOMER LTD. (JP) | 2005-01-13 | — | — | US | disclosed |