SCHEMBL31501546

SCHEMBL31501546

CC(C)(C)[Si](C)(C)OCC(CS(=O)(=O)O)c1ccc(F)cn1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
APLNR P35414 7/20 0.40
GABRA5 P31644 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31037695 0.81 TSHR (0.39)
SCHEMBL26743081 0.78 APLNR (0.40) APLNR
SCHEMBL31566400 0.78 APLNR (0.40) APLNR
SCHEMBL31392865 0.77 APLNR (0.40) APLNR
SCHEMBL26621129 0.75 APLNR (0.33) APLNR
SCHEMBL15300270 0.75 GABBR2 (0.36)
SCHEMBL31501537 0.72 APLNR (0.54) APLNR
SCHEMBL24707461 0.72 APLNR (0.39) APLNR
SCHEMBL31739278 0.69
SCHEMBL31507685 0.68 GABRA5 (0.34) APLNRGABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250270211-A1 COMPOUNDS FOR FGFR INHIBITION COGENT BIOSCIENCES, INC. 2025-08-28 US disclosed
US-12351581-B2 Compounds for FGFR inhibition COGENT BIOSCIENCES, INC. (US) 2025-07-08 US disclosed
US-20250066352-A1 COMPOUNDS FOR FGFR INHIBITION COGENT BIOSCIENCES, INC. 2025-02-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066352-A1 COMPOUNDS FOR FGFR INHIBITION FGFR1, FGFR4, FGFR3 APLNR 1247/4885GABRA5 1263/4885
US-20250270211-A1 COMPOUNDS FOR FGFR INHIBITION FGFR1, FGFR4, FGFR3 APLNR 1247/4885GABRA5 1263/4885
US-12351581-B2 Compounds for FGFR inhibition FGFR1, FGFR4, FGFR3 APLNR 1247/4885GABRA5 1263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.