Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146031 | 0.88 | MKNK1 (0.50) | MKNK1MKNK2XDHSLC22A12PIK3CG | |
| SCHEMBL3155830 | 0.87 | SCN10A (0.42) | MKNK1MKNK2EGLN1XDHSLC22A12 | |
| SCHEMBL3146052 | 0.84 | EGLN1 (0.43) | MKNK1MKNK2EGLN1XDHAKT1 | |
| SCHEMBL3260284 | 0.83 | MKNK1 (0.37) | MKNK1MKNK2DYRK1ACHRNB1CHRNB2 | |
| SCHEMBL3260277 | 0.83 | MKNK1 (0.37) | MKNK1MKNK2DYRK1ACHRNB1CHRNB2 | |
| SCHEMBL3137063 | 0.83 | XDH (0.43) | MKNK1MKNK2EGLN1XDHSLC22A12 | |
| SCHEMBL3151913 | 0.82 | MKNK1 (0.43) | MKNK1MKNK2PIK3CGGSK3BDYRK1A | |
| SCHEMBL3150661 | 0.81 | CYP11B2 (0.35) | MKNK1MKNK2XDHSLC22A12GSK3B | |
| SCHEMBL3145987 | 0.81 | CYP11B1 (0.40) | MKNK1MKNK2CDK8GSK3BDYRK1A | |
| SCHEMBL3154853 | 0.80 | CHRNB2 (0.45) | MKNK1MKNK2SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979321-B9 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2010-02-17 | — | — | EP | disclosed |
| EP-1979321-B1 | NOVEL PYRIDINYLAMINOALKYLENE- AND PYRIDINYLOXYALKYLENE-CYCLOPROPANAMINES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SERVIER LAB (FR) | 2009-07-29 | — | — | EP | disclosed |