Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 6/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.33 |
| ▸ | SRC | P12931 | 5/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | ABL1 | P00519 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | HCK | P08631 | 4/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.33 |
| ▸ | MTOR | P42345 | 4/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.33 |
| ▸ | PRKDC | P78527 | 4/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20555738 | 0.90 | SIGMAR1 (0.36) | PIK3CAPIK3CDPIK3CBPIK3CGFAAH | |
| SCHEMBL17506671 | 0.89 | FAAH (0.40) | FAAHMGLLLRRK2RETSIGMAR1 | |
| SCHEMBL24884453 | 0.85 | KIT (0.33) | SIGMAR1 | |
| SCHEMBL20456694 | 0.79 | FAAH (0.33) | PIK3CAFAAHMGLLLRRK2SIGMAR1 | |
| SCHEMBL20456693 | 0.79 | FAAH (0.33) | PIK3CAFAAHMGLLLRRK2SIGMAR1 | |
| SCHEMBL24884253 | 0.79 | MAP3K12 (0.34) | PIK3CAMTORLRRK2SIGMAR1MAP3K12 | |
| SCHEMBL24915326 | 0.77 | FAAH (0.34) | KDRPIK3CASRCPIK3CDABL1 | |
| SCHEMBL22497231 | 0.76 | SOST (0.34) | KDRPIK3CASRCPIK3CDABL1 | |
| SCHEMBL3246939 | 0.76 | SIGMAR1 (0.36) | SIGMAR1 | |
| SCHEMBL3432373 | 0.76 | SIGMAR1 (0.39) | PI4KBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12384773-B2 | Thiazole compounds and methods of use thereof | ARCUS BIOSCIENCES, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| WO-2025096979-A1 | THIAZOLE COMPOUNDS AS KIT INHIBITORS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| US-20250145606-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2025-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12384773-B2 | Thiazole compounds and methods of use thereof | TPMT, CYP11B2, ABAT | KDR 4203/4885PIK3CA 3424/4885SRC 1808/4885 |
| US-20250145606-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | TPMT, CYP11B2, ABAT | KDR 4203/4885PIK3CA 3424/4885SRC 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.